Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.
نویسندگان
چکیده
Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.
منابع مشابه
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 365 Pt 1 شماره
صفحات -
تاریخ انتشار 2002